A population study on the UGT1A1*28 variant associated to Irinotecan tolerance

Roman R,1 Colomer A,1 Erill N,1 Verdú M,2 Ibáñez R,1 Cordon-Cardo C,1 Puig X.1,2

1BIOPAT. Biopatologia Molecular, Grup Assistència & 2HISTOPAT Laboratoris, Barcelona, Catalonia, Spain.

Background: Irinotecan (CPT-11) is currently used as first- or second-line treatment for colorectal cancer, either alone or in combination with 5-fluorouracil based regimens. UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the inactivation of SN-38, the active metabolite of irinotecan, through glucuronidation. UGT1A1*28, a polymorphic variant of this enzyme displaying an additional TA dinucleotide in the promoter TATA box, has been […]

2006-09-23T17:11:42+00:00

Estudio mutacional de BRAF y KRAS en cáncer colorrectal: carcinoma esporádico versus síndrome familiar no asociado a poliposis

A Colomer1, N Erill1, A Vidal1, 2, M Verdú2, R Román1, C. Cordón3, X Puig1,2.

1 BIOPAT. Biopatologia Molecular.  Grup Assistència. Barcelona. 2 Histopat laboratoris, Barcelona. 3 Division of Molecular Pathology, Memorial Sloan-Kettering Cancer Center, New York. 

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Póster presentado en:

X Congreso Nacional de la Sociedad Española de Oncología Médica 2005

2005-09-01T01:17:23+00:00

La inestabilidad de microsatélites en el cáncer colorrectal puede predecirse en base al fenotipo tumoral

A Colomer1, N Erill1, A Vidal1,2, M Calvo3, R Román1, M Verdú2, C Cordón 4, X Puig 1,2.

1 BIOPAT. Biopatologia Molecular.  Grup Assistència. Barcelona. 2 Histopat laboratoris, Barcelona. 3 Departamento de Estadística de la Universidad de Barcelona. Barcelona.  4 Division of Molecular Pathology, Memorial Sloan-Kettering Cancer Center, New York. 

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Póster presentado en:

XXII Congreso de la Sociedad Española de Anatomía Patológica 2005

 

2005-09-01T01:12:41+00:00

A novel multiplexing PCR-based assay of the anaylisis of chromosome 18q status in colorectal cancer

Nadina Erill1, Anna Colomer1, Miquel Calvo2, August Vidal3, Ruth Román1, Montse Verdú3, Carlos Cordón-Cardó4, Xavier Puig1,3.

1BIOPAT, Grup Assistència, Statistics Department, 2Universitat de Barcelona, 3HISTOPAT Laboratoris, Barcelona, and 4Division of Molecular Pathology,  Memorial Sloan-Kettering Cancer Center,  New York.

Chromosome 18q allelic loss has been reported to have prognostic significance in stage II colorectal carcinoma. We have developed a fluorescent multiplex polymerase chain reaction assay to analyze five microsatellite markers (D18S55, D18S58, D18S61, D18S64 and D18S69) for allelic loss determination at the long […]

2005-07-23T17:07:51+00:00

A novel logistic model based on clinicopathological features predicts microsatellite instability in colorectal carcinomas

Anna Colomer1, Nadina Erill1, August Vidal2, Miquel Calvo3, Ruth Román1, Montse Verdú2, Carlos Cordon-Cardo4, Xavier Puig 1,2.

1BIOPAT, Grup Assistència, Barcelona; 2HISTOPAT Laboratoris, Barcelona; 3Statistics Department of the Universitat de Barcelona, Barcelona and 4Division of Molecular Pathology, Memorial Sloan-Kettering Cancer Center, New York.

 

High-frequency microsatellite instability has been reported to be associated with good prognosis in colorectal adenocarcinoma. However, methods to assess microsatellite instability (MIN) are based on genetic assays, and are not ideally suited to […]

2005-07-23T17:06:28+00:00