KRAS, NRAS and BRAF mutation profiling in a series of 90 metastasic colorectal cancer spanish patients. An estimation of cost savings.

Rodón Natalia1, Román Ruth1, Verdú Montse1,2, Montes Mª del Mar3, García-Peláez Beatriz1, Diaz Olga1, Lacasa Carmen3 and Puig Xavier1,2.

1 BIOPAT. Biopatologia Molecular S.L., Barcelona (Spain). 2 HISTOPAT Laboratoris S.L., Barcelona (Spain). 3 Departamento de Farmacia. Hospital de Barcelona (SCIAS), Grup Assistència, Barcelona (Spain).

Background: Metastasic colorectal cancer (mCRC) patients harbouring a mutation in codon 12 or 13 of the KRAS does not benefit from therapy with antibodies targeting epidermal growth factor receptor (EGFR). Recently, several studies have shown that an extended study […]

2015-04-06T20:07:45+00:00

Prospective validation of the microsatellite instability prediction models: RERtest6 and RERtest8

Román R.a, Rodón N.a, Verdú M.a,c, Calvo M.d, García-Peláez B.a, Díaz O.a, Biern G.a, Serrano T.c, Puig X.a,b,c

a BIOPAT, Biopatologia Molecular SL, Grup Assistència, Barcelona, Spain. b Hospital de Barcelona-SCIAS, Grup Assistència, Barcelona. Spain. c Histopat Laboratoris, Barcelona, Spain. d Statistics Department, Universitat de Barcelona, Barcelona, Spain.

 

Resumen

El estudio de la inestabilidad de microsatélites (MSI) es altamente recomendable en todos los carcinomas colorrectales, tanto como una primera aproximación para identificar posibles pacientes con síndrome de Lynch, como debido a su valor […]

2014-10-26T19:48:13+00:00

Validació prospectiva dels models predictius d’inestabilitat de microsatèl.lits RERtest6 i RERtest8 en els carcinomes colorectals

Román R1, Rodón N1, Verdú M1,3, García B1, Díaz O1, Biern G1, Serrano T3, Calvo M4, Puig X1,2,3.

1BIOPAT. Biopatologia Molecular, SL, Grup Assistència; 2Hospital de Barcelona, SCIAS, Grup Assistència; 3Histopat Laboratoris, 4Department d’Estadística, Universitat de Barcelona.

 

Introducció

L’estudi d’inestabilitat de microsatèl•lits (MSI-H), està recomanat per les guies SEAP/SEOM en tots els casos de càncer colorectal com a cribratge de pacients amb síndrome de Lynch, emfatitzat en estadi II degut al seu valor com a factor de bon pronòstic i possible pitjor resposta […]

2014-06-16T17:00:53+00:00

Clinicopathological and molecular characterization of colorectal micropapillary carcinoma

Montse Verdú1,2, Ruth Román1, Miquel Calvo3, Natàlia Rodón1, Beatriz García1, Marta González1, August Vidal1,2, and Xavier Puig1,2,4.

1BIOPAT. Biopatologia Molecular, SL, Grup Assistencia, Barcelona, Spain; 2 Histopat Laboratoris, Barcelona, Spain; 3Statistics Department, Universitat de Barcelona, Barcelona, Spain and 4Hospital de Barcelona, SCIAS, Grup Assistencia, Barcelona, Spain.

Abstract

Invasive micropapillary carcinoma is associated with frequent lymph node metastasis and adverse clinical outcome. Initially described as a variant of breast and ovarian carcinoma, it has subsequently been found in other organs, most recently the colon. Reports of […]

2011-05-06T16:22:05+00:00

Microsatellite instability of the colorectal carcinoma can be predicted in the conventional pathologic examination. A prospective multicentric study and the statistical analysis of 615 cases consolidate our previously proposed logistic regression model

R Román1, M Verdú1,3,  M Calvo 4, A Vidal3,5,,X Sanjuan 5, M Jimeno6, A Salas7, J Autonell 8, I Trias9, M González1, B García1, N Rodón1 and X Puig1,2,3.

1BIOPAT.Biopatologia Molecular, Barcelona, Spain; 2Hospital de Barcelona, Barcelona, Spain; 3Histopat Laboratoris, Barcelona, Spain; 4Statistics Department, Universitat de Barcelona, Barcelona, Spain; 5Hospital Universitari de Bellvitge, Barcelona, Spain; 6Hospital del Mar, Barcelona, Spain; 7Hospital Mútua de Terrassa, Terrasa, Spain; 8Hospital General de Vic, Vic, Spain and 9Hospital Plató, Barcelona, Spain.

Abstract

High microsatellite instability (MSI-H) allows the identification […]

2010-09-10T01:20:55+00:00