Concordance Analysis Between Microsatellite Instability Status and Tumor Mutational Burden in Colorectal Cancer Patients: A Nested Case-Control Study.
Natalia Rodon1, Yessica No Garbarino1, Olga Diaz1 and Xavier Puig1,2,3.
1BIOPAT. Biopatologia Molecular SL. Grup Assistència. Barcelona, Spain. 2HISTOPAT SL. Barcelona, Spain. 3SCIAS-Hospital de Barcelona, Grup Assistència. Barcelona, Spain.
Mismatch repair (MMR) deficiency and microsatellite instability (MSI) are approved predictive biomarkers of PD1/PD-L1 therapy in colorectal cancer (CRC) patients. Tumor Mutational Burden (TMB) quantifies the number of somatic mutations in tumoral DNA and is reported as number of mutations per DNA Megabase (mut/Mb). TMB is being investigated as a novel predictive biomarker […]