BRAF mutations in colorectal cancer are linked to loss of hMLH1 expression and proximal location, while independent of K-RAS activation
Anna Colomer 1, Nadina Erill 1, August Vidal 2, Ruth Román 1, Montse Verdú 2, Carlos Cordon-Cardo 3, Xavier Puig 1,2.
1BIOPAT, Grup Assistència, Barcelona, Spain; 2HISTOPAT Laboratoris, Barcelona, Spain; 3Division of Molecular Pathology, Memorial Sloan-Kettering Cancer Center, New York.
The RAF gene family encodes RAS-regulated kinases that mediate cellular responses to growth signals. Mutations within the BRAF gene occur in about 10% of colorectal cancers, and are significantly associated to defective mismatch repair (MMR) due […]