Genetic alterations of the epidermal growth factor receptor pathway in a series of non-small cell lung cancer characterized by morphology and immunophenotype
Verdú M,1 Colomer A,1 Erill N,1 Roman R,2 Górriz M, 1,2 Ibáñez R,1 Cordon-Cardo C,1 Puig X.1,2
1HISTOPAT Laboratoris, Barcelona, Catalonia, Spain & 2BIOPAT. Biopatologia Molecular, Grup Assistència.
Background: Non-small cell lung cancer (NSCLC) is classified in two main categories: adenocarcinoma (AC), which includes bronchioloalveolar carcinoma (BAC), and squamous cell carcinoma (SCC). Activating mutations and increased copy number of the EGFR gene have been reported in tumors from patients with NSCLC with increased response rate to tyrosine kinase inhibitors (TKIs). There is […]