Ki-67 and P16INK4A immunoexpression strongly correlates with increasing grade of CIN and HPV infection

Montse Verdú 1,3, Ruth Roman1, Carme Pubill3, Miquel Calvo 4, August Vidal 1,3 Beatriz García1, Marta González1, Natalia Rodón1 and Xavier Puig1,2,3.

1BIOPAT. Biopatologia Molecular, SL, Grup Assistència; 2Hospital de Barcelona SCIAS, Grup Assistència; 3Histopat Laboratoris and 4Statistics Department, Universitat de Barcelona. Barcelona, Spain.

Background: MIB-1 immunoquantitative features have been correlated with the grade of dysplasia in cervical epithelium, while P16 accumulation has been related to the presence of high grade intraepithelial lesions (HSIL) and detection of human papillomavirus (HPV). The aim […]


Human papillomavirus and anogenital pathology

Román R1, Colomer A1, Erill N1, Calvo M3, Verdú M2, Cordon-Cardo C4, Puig X1,2.

1BIOPAT, 2HISTOPAT Laboratoris and 3Statistics Dept. of the Universitat de Barcelona, Spain; and 4Division of Molecular Pathology, Memorial Sloan-Kettering Cancer Center, New York.

Human papillomavirus (HPV) is the main etiologic factor for cervical cancer and its types are classified into low and high oncogenic risk according to their capability of inducing invasive tumors. We studied 978 paraffin-embedded anogenital biopsies (730 cervical plus 248 extracervical) for the presence of […]