Ki-67 and P16INK4A immunoexpression strongly correlates with increasing grade of CIN and HPV infection

Montse Verdú 1,3, Ruth Roman1, Carme Pubill3, Miquel Calvo 4, August Vidal 1,3 Beatriz García1, Marta González1, Natalia Rodón1 and Xavier Puig1,2,3.

1BIOPAT. Biopatologia Molecular, SL, Grup Assistència; 2Hospital de Barcelona SCIAS, Grup Assistència; 3Histopat Laboratoris and 4Statistics Department, Universitat de Barcelona. Barcelona, Spain.

Background: MIB-1 immunoquantitative features have been correlated with the grade of dysplasia in cervical epithelium, while P16 accumulation has been related to the presence of high grade intraepithelial lesions (HSIL) and detection of human papillomavirus (HPV). The aim […]

2008-05-23T17:57:38+00:00

Colo-rectal micropapillary carcinoma: a clinicopathological and molecular study of 27 cases

Ruth Roman1, Montse Verdú 1,3, August Vidal 1,3, Miquel Calvo 4, Natalia Rodón1, Beatriz García1, Marta González1 and Xavier Puig1,2,3.

1BIOPAT. Biopatologia Molecular, SL, Grup Assistencia; 2Hospital de Barcelona SCIAS, Grup Assistència; 3Histopat Laboratoris and 4Statistics Department, Universitat de Barcelona. Barcelona, Spain.

INTRODUCTION: Invasive micropapillary carcinoma (MC) is associated with frequent lymph node metastasis and adverse clinical outcome. It has been reported in ovary, breast, urinary bladder, ureter, lung, parotid gland and, recently, in colon. Little is known about the morphological and […]

2008-05-23T17:13:35+00:00