Cáncer colorectal: marcadores de pronóstico y orientación terapéutica.
Anna Colomer Valero, Manuel Guix Pericas
BIOPAT. Biopatología molecular, S.L. Grup Assistència.
MSI status modulates the value of some molecular markers in colorectal tumors
A. Colomer, N. Erill, M. Verdú, R. Román, A Vidal, X. Puig.
BIOPAT. Biopatologia Molecular, SL. Barcelona, Spain.
LOH 17p/TP53 and LOH 18q/DCC have been related to prognosis of colorectal adenocarcinomas. Since MSI-H tumors have a minor rate of TP53 mutations and rarely present allelic deletions, we intended to study these molecular features in a series of 197 primary tumors previously categorized for MSI status. Eighteen tumors out of 181 (10%) exhibited MSI-H. p53 alterations were approached by a combination of […]
TP53, 17P and 18Q alterations as prognostic markers in MSS colorectal adenocarcinomas
Anna Colomer1, Nadina Erill1, Montse Verdú2, Ruth Román1, August Vidal1,2, Xavier Puig1,2.
1BIOPAT, Biopatologia Molecular, Barcelona, Spain. 2Histopat Laboratoris, Barcelona, Spain.
Two different patterns have been described for colorectal tumorigenesis. The main one -affecting 85% of sporadic tumors- is based on the familial adenomatous polyposis (FAP) model, a multistep process that involves at least APC, K-RAS, DCC andTP53 genes. The second pathway shares its etiology with hereditary non-polyposis colorectal cancer (HNPCC), and is characterized by mutations at the mismatch repair genes (MMR) that lead […]