Highly sensitive real-time PCR for the detection of EGFR mutations in lung adenocarcinoma. Is it worth it?
Rodon Natalia1, Roman Ruth1, Verdu Montse1,3, Garcia Beatriz1, Pujol Merce1 and Puig Xavier 1,2,3.
1BIOPAT.Biopatologia Molecular, SL, Grup Assistencia, Barcelona, Spain; 2Hospital de Barcelona, SCIAS, Grup Assistencia, Barcelona, Spain; 3Histopat Laboratoris, Barcelona, Spain.
Background: Mutations involving the epidermal growth factor receptor (EGFR) correlate with responsiveness to tyrosine kinase inhibitors (TKIs), which significantly improves patient survival in lung adenocarcinoma (AC). These mutations are described to be more frequent in non-mucinous lepidic adenocarcinomas (nmBAC). The unquestionable importance of determining the presence of these mutations, even in samples with […]