colon archivos - Histopat laboratoris

Concordance analysis between liquid biopsy (ctDNA) and tumor DNA molecular profiles from panel-based next-generation sequencing.

Natalia Rodon Font^a , Yessica No Garbarino^a, Olga Díaz Castello^a, Juan Moya Amoros^{b, c}, Pedro Barrios Sánchez^{c, d}, David Coroleu Lletget^c, Mª Antonia Lequerica Cabello^c, Joan Borras Marcet^c, Sandra Mecho Meca^e, Isabel Escape^e, Javier Martinez-Agea^e, Estefania Garcia^f, Marta Ferrer^f y Xavier Puig Torrus^{a, g, h}.

^aBIOPAT, Biopatologia Molecular SL. Grup Assistència. Avenida Diagonal, 660. 08034 Barcelona, España.

^bEx-jefe de Servicio de Cirugía torácica del Hospital Universitario de Bellvitge y Catedratico de Universidad acreditado (ANECA).

^cServicio de Cirugía del […]

adm-aguardiola 2022-07-12T13:06:27+00:00

Concordance Analysis Between Microsatellite Instability Status and Tumor Mutational Burden in Colorectal Cancer Patients: A Nested Case-Control Study.

Natalia Rodon¹, Yessica No Garbarino¹, Olga Diaz1 and Xavier Puig^1,2,3.

¹BIOPAT. Biopatologia Molecular SL. Grup Assistència. Barcelona, Spain. ²HISTOPAT SL. Barcelona, Spain. ³SCIAS-Hospital de Barcelona, Grup Assistència. Barcelona, Spain.

BACKGROUND

Mismatch repair (MMR) deficiency and microsatellite instability (MSI) are approved predictive biomarkers of PD1/PD-L1 therapy in colorectal cancer (CRC) patients. Tumor Mutational Burden (TMB) quantifies the number of somatic mutations in tumoral DNA and is reported as number of mutations per DNA Megabase (mut/Mb). TMB is being investigated as a novel predictive biomarker […]

adm-aguardiola 2020-03-09T18:03:37+00:00

Biopsia Líquida (ctDNA) vs Tumor Sólido (FFPE). Comparación de los perfiles moleculares obtenidos mediante NGS en carcinoma pulmonar y colorrectal.

Natalia Rodon¹, Yessica No Garbarino¹, Montse Verdu^1,2, Olga Diaz¹, Esther Llaudet1, Juan Moya³, David Coroleu⁴, Pedro Barrios⁴, Mª Antonia Lequerica⁴, Joan Borras⁴, Sandra Mecho⁵, Ferran Bastart⁵, Javier Martinez-Agea⁵ y Xavier Puig^1,2,6.

¹BIOPAT. Biopatologia Molecular SL. Grup Assistència. Barcelona, Spain. ²HISTOPAT SL. Barcelona, Spain. ³Especialista Cirugía Torácica. Servicio de Cirugía. SCIAS-Hospital de Barcelona, Grup Assistència. Barcelona, Spain. ⁴Servicio de Cirugía. SCIAS-Hospital de Barcelona, Grup Assistència. Barcelona, Spain. ⁵Servicio Diagnóstico por la Imagen. SCIAS-Hospital de Barcelona, Grup Assistència. Barcelona, Spain. ⁶SCIAS-Hospital de Barcelona, […]

adm-aguardiola 2019-05-27T11:11:22+00:00

Comparison Between Matched Liquid Biopsy (ctDNA) and FFPE Tumors Molecular Profiles of Lung and Colorectal Cancer Patients in a Molecular Diagnostics Laboratory.

Natalia Rodon¹, Yessica No Garbarino¹, Montse Verdu^1,2, Olga Diaz1, Esther Llaudet¹, Juan Moya³, David Coroleu⁴, M. Antonia Lequerica⁴, Pedro Barrios⁴, Joan Borras⁴, Sandra Mecho⁵, Ferran Bastart⁵, Javier Martinez-Agea⁵ and Xavier Puig^1,2,6.

¹BIOPAT. Biopatologia Molecular SL. Grup Assistència. Barcelona, Spain. ²HISTOPAT SL. Barcelona, Spain.³Especialista Cirugía Torácica. Servicio de Cirugía. SCIAS-Hospital de Barcelona, Grup Assistència. Barcelona, Spain. ⁴Servicio de Cirugía. SCIAS-Hospital de Barcelona, Grup Assistència. Barcelona, Spain. ⁵Servicio Diagnóstico por la Imagen. SCIAS-Hospital de Barcelona, Grup Assistència. Barcelona, Spain. ⁶SCIAS-Hospital de Barcelona, […]

adm-aguardiola 2019-04-01T10:30:07+00:00

Molecular Profiling of Lung and Colorectal Cancer: Added Value of Next Generation Sequencing

Natalia Rodon¹, Olga Diaz¹, Montse Verdu^1,2, Yessica No Garbarino¹ and Xavier Puig^1,2,3.

¹BIOPAT. Biopatologia Molecular SL. Grup Assistència. Barcelona, Spain. ²HISTOPAT SL. Barcelona, Spain. ³Hospital de Barcelona, Grup Assistència. Barcelona, Spain.

Background and objectives

The results of DNA and RNA molecular profiles obtained from non-small cell lung cancer (NSCLC) and colorectal patients (CRC) since the implementation of a Next Generation Sequencing (NGS) panel in a diagnostic laboratory setting were analyzed. A review of the detected mutations in its clinicopathological context was performed and […]

adm-aguardiola 2018-12-30T20:40:21+00:00

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